REF:

C3106 (Multiple Cassette)

INTENDED USE：

Dengue NS-1 Antigen + IgG/IgM Antibody Multiple Test is an immunoassay that uses double-antibody sandwich method for qualitative detection of dengue virus NS-1 antigen and immuno-capture method for qualitative detection of anti-dengue virus IgG and IgM antibodies from serum, plasma and whole blood specimens of human. This device performed manually. Performance of the test is limited to laboratory professional use.

SUMMARY：

Dengue is a highly endemic infectious disease of the tropical countries. Dengue virus is transmitted within humans through female aedes, 99% of which are caused by just two species, Aedes aegypti and Aedes albopictus. Classic dengue fever is primarily a disease of older children and adults. The incubation period varies from 3 to 14 days (average 4 to 7 days). Dengue virus has four antigenically distinct serotypes, DENV-1 to DENV-4, with different genotypes and three structural proteins and seven non-structural proteins. Amount of NS-1 antigen is raised quickly during the acute phase of dengue infection, regardless of whether it is a primary or secondary infection. Immune response includes IgM antibodies produced 5 days after symptoms onset and persist for 30-60 days. Secondary infections often result in high fever and in many cases with haemorrhagic events and circulatory failure. Immune response includes IgG antibodies rise in 1-2 days and IgM response after 20 days of infection. Current dengue test methods include: MSE antigen test, RNA nucleic acid test and the RDTs. As a RDT product, Dengue NS-1 Antigen + IgG/IgM Antibody Multiple Test is intuitive, fast, easy to interpret results.