Cat.No.: DNG 431/432/433
Dengue IgG / IgM Rapid Test is a solid phase immunochromatographic assay for the rapid, qualitative and differential detection of IgG and IgM antibodies to dengue virus in human serum, plasma or whole blood. This test is intended for professional use to aid in the presumptive diagnosis between primary and secondary dengue infection. This test provides only a preliminary test result. Therefore, isolation of virus, antigen detection in fixed tissues, RT-PCR and serological test like haemagglutination-inhibition test, more specific alternative diagnosis method must be used in order to obtain a confirmation of dengue virus infection.
SUMMARY AND EXPLANATION:
Dengue viruses, transmitted by the mosquito, Aedes aegypti and Aedes albopictus mosquitoes, are widely distributed throughout the tropical and subtropical areas of the world. There are four known distinct serotypes (dengue virus 1,2,3 and 4). In children, infection is often subclinical or causes a self-limited febrile disease. However, if the patient is infected second times with a different serotype, a more severe disease, dengue hemorrhagic fever or dengue shock syndrome, is more likely to occur. Dengue is considered to be the most important arthropod-borne viral disease due to the human morbidity and mortality it causes.
Traditionally, the serological diagnosis of an acute dengue virus infection has relied on showing a 4-fold or greater rise in anti-dengue virus antibody between paired acute- and convalescent-phase sera from a patient. The haemagglutination-inhibition test has been the most commonly used serological assay for dengue diagnosis.
Rapid and reliable tests for primary and secondary infections of dengue are essential for patient management. Primary Dengue infection is associated with mild to high fever, headache, muscle pain and skin rash. Immune response includes IgM antibodies produced by 5th day of symptoms and persist for 30—60 days. IgGs appear the 14th day and persist for life. Secondary infections often result in high fever and in many cases with haemorrhagic events and circulatory failure. Secondary infections show that IgGs rise within 1-2 days after the onset of symptoms and induce IgM response after 20 days of infection.
Test Procedure & Result Interpretation:
Ordering Reference Information:
|Cat.No||Description of Products||Format||Packing Size||Specimen|
|DNG 431||Dengue IgG/IgM Test||Cassette||25T||Serum/WB/Plasma|
|DNG 432||Dengue NS-1 Antigen Test||Cassette||25T||Serum/WB/Plasma|
|DNG 433||Dengue NS-1 & Dengue IgG/IgM Test||Cassette||25T||Serum/WB/Plasma|