Cat.No.: HBV 909/910
This kit is an enzyme-linked immunosorbent assay (ELISA) for qualitative determination of IgM-class antibodies to hepatitis A virus in human serum or plasma. It is intended for use in clinical laboratories for diagnosis of acute hepatitis A and managements of patients related to infection with hepatitis A virus.
SUMMARY AND EXPLANATION:
Hepatitis A is a self-limited disease and chronic stage or other complications are rare. Infections occur early in life in areas where sanitation is poor and living conditions are crowded. With improved sanitation and hygiene, infections are delayed and consequently the number of persons susceptible to the disease increases. Because the disease is transmitted through the fecal-oral route in dense populated regions, an outbreak can arise from single contaminated source. The cause of hepatitis A is hepatitis A virus (HAV)-non enveloped positive strand RNA virus with a linear single strand genome, encoding for only one known serotype. HAV has four major, structural polypeptides and it localizes exclusively in the cytoplasm of human hepatocytes. The infection with HAV induces strong immunological response and elevated levels first of IgM and then IgG are detectable within a few days after the onset of the symptoms. The presence of anti–HAV IgM is an important serological marker for early detection and observation of the clinical manifestation of the disease. Increasing levels of anti-HAV IgM are detectable about three weeks after exposure with highest titter after four to six weeks later. Within six months after infection IgM concentration declines to non-detectable levels.
Ordering Reference Information:
|Cat.No||Description of Products||Format||Packing Size||Specimen|
|HBV 909||HAV-IgM Test Kit||Microplate||96T||Serum/Plasma|
|HBV 910||HAV-Ab Test Kit||Microplate||96T||Serum/Plasma|